{"id":231212,"date":"2026-02-12T13:10:03","date_gmt":"2026-02-12T19:10:03","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/the-tub-variant-impairs-leptin-sensitivity-and-agrp-neuronal-response-leading-to-obesity"},"modified":"2026-02-12T13:10:03","modified_gmt":"2026-02-12T19:10:03","slug":"the-tub-variant-impairs-leptin-sensitivity-and-agrp-neuronal-response-leading-to-obesity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/the-tub-variant-impairs-leptin-sensitivity-and-agrp-neuronal-response-leading-to-obesity","title":{"rendered":"The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-tub-variant-impairs-leptin-sensitivity-and-agrp-neuronal-response-leading-to-obesity2.jpg\"><\/a><\/p>\n<p>What are the genetic origins of early-onset obesity?<\/p>\n<p>Studying a cohort of young adults in China, researchers in <i>Science <\/i>TranslationalMedicine performed deep sequencing and identified a loss-of-function variant in the gene TUB that impairs sensitivity to leptin.<\/p>\n<hr>\n<p>Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation, leading to hyperphagic obesity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What are the genetic origins of early-onset obesity? Studying a cohort of young adults in China, researchers in Science TranslationalMedicine performed deep sequencing and identified a loss-of-function variant in the gene TUB that impairs sensitivity to leptin. Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation, leading to hyperphagic obesity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-231212","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231212"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231212\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}