{"id":231201,"date":"2026-02-12T09:09:46","date_gmt":"2026-02-12T15:09:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/snap-25-disease-variants-affect-synaptic-transmission-by-destabilizing-snare-complexes-within-a-multimeric-snare-ring"},"modified":"2026-02-12T09:09:46","modified_gmt":"2026-02-12T15:09:46","slug":"snap-25-disease-variants-affect-synaptic-transmission-by-destabilizing-snare-complexes-within-a-multimeric-snare-ring","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/snap-25-disease-variants-affect-synaptic-transmission-by-destabilizing-snare-complexes-within-a-multimeric-snare-ring","title":{"rendered":"SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/snap-25-disease-variants-affect-synaptic-transmission-by-destabilizing-snare-complexes-within-a-multimeric-snare-ring.jpg\"><\/a><\/p>\n<p>Vold et al. studied two SNAP-25 variants with different clinical severity. Variants destabilize the SNARE complex and reduce binding to the Munc18-1:VAMP2:syntaxin-1 acceptor complex, with correlated effects on neurotransmitter release. Effects of co-expression of variant and wild-type SNAP-25 were modeled by assuming the co-existence of both species in a ring of SNARE complexes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vold et al. studied two SNAP-25 variants with different clinical severity. Variants destabilize the SNARE complex and reduce binding to the Munc18-1:VAMP2:syntaxin-1 acceptor complex, with correlated effects on neurotransmitter release. Effects of co-expression of variant and wild-type SNAP-25 were modeled by assuming the co-existence of both species in a ring of SNARE complexes.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231201","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231201"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231201\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}