{"id":231122,"date":"2026-02-11T14:24:57","date_gmt":"2026-02-11T20:24:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/large-scale-proteomics-reveals-new-candidate-biomarkers-for-late-onset-preeclampsia"},"modified":"2026-02-11T14:24:57","modified_gmt":"2026-02-11T20:24:57","slug":"large-scale-proteomics-reveals-new-candidate-biomarkers-for-late-onset-preeclampsia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/large-scale-proteomics-reveals-new-candidate-biomarkers-for-late-onset-preeclampsia","title":{"rendered":"Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/large-scale-proteomics-reveals-new-candidate-biomarkers-for-late-onset-preeclampsia2.jpg\"><\/a><\/p>\n<p>RESEARCH ARTICLE: large-scale proteomics reveals new candidate biomarkers for late-onset preeclampsia.<\/p>\n<hr>\n<p>BACKGROUND: Preeclampsia is classified as either a more severe early onset or a more prevalent late-onset form. Lower PlGF (placental growth factor) and increased sFlt-1 (fms-like tyrosine kinase-1) in maternal circulation are promising biomarkers, yet they lack specificity for preeclampsia. METHODS: We quantified \u22487000 proteins in 673 samples collected from 89 patients with late-onset preeclampsia and 91 controls at T1 (15\u201322), T2 (22\u201330), and T3 (30\u201342) weeks. Elastic net and random forest models were fitted and evaluated by cross-validation. Differential abundance analysis followed by functional profiling, was used to identify and interpret protein changes. RESULTS: An increase in protein differential abundance in late-onset preeclampsia was observed with advancing gestation, reaching 806 proteins at T3 related to angiogenesis, cell adhesion, and extracellular matrix remodeling.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RESEARCH ARTICLE: large-scale proteomics reveals new candidate biomarkers for late-onset preeclampsia. BACKGROUND: Preeclampsia is classified as either a more severe early onset or a more prevalent late-onset form. Lower PlGF (placental growth factor) and increased sFlt-1 (fms-like tyrosine kinase-1) in maternal circulation are promising biomarkers, yet they lack specificity for preeclampsia. METHODS: We quantified \u22487000 [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-231122","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231122"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231122\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}