{"id":231121,"date":"2026-02-11T14:23:57","date_gmt":"2026-02-11T20:23:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-single-oncolytic-virus-injection-may-help-t-cells-infiltrate-glioblastoma"},"modified":"2026-02-11T14:23:57","modified_gmt":"2026-02-11T20:23:57","slug":"a-single-oncolytic-virus-injection-may-help-t-cells-infiltrate-glioblastoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/a-single-oncolytic-virus-injection-may-help-t-cells-infiltrate-glioblastoma","title":{"rendered":"A single oncolytic virus injection may help T cells infiltrate glioblastoma"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-single-oncolytic-virus-injection-may-help-t-cells-infiltrate-glioblastoma.jpg\"><\/a><\/p>\n<p>A team led by investigators at Mass General Brigham and Dana-Farber Cancer Institute has shown that a single injection of an oncolytic virus\u2014a genetically modified virus that selectively infects and destroys cancer cells\u2014can recruit immune cells to penetrate and persist deep within brain tumors. The research, which is <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01504-1\" target=\"_blank\">published<\/a> in <i>Cell<\/i>, provides details on how this therapy prolonged survival in patients with glioblastoma, the most common and malignant primary brain tumor, in a recent clinical trial.<\/p>\n<p>\u201cPatients with glioblastoma have not benefited from immunotherapies that have transformed patient care in other cancer types such as melanoma because glioblastoma is a \u2018cold\u2019 tumor with poor infiltration by cancer-fighting immune cells,\u201d said co-senior author Kai Wucherpfennig, MD, Ph.D., chair of the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute.<\/p>\n<p>\u201cFindings from our clinical trial and our mechanistic study show that it is now feasible to bring these critical immune cells into glioblastoma.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team led by investigators at Mass General Brigham and Dana-Farber Cancer Institute has shown that a single injection of an oncolytic virus\u2014a genetically modified virus that selectively infects and destroys cancer cells\u2014can recruit immune cells to penetrate and persist deep within brain tumors. The research, which is published in Cell, provides details on how [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-231121","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231121","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231121"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231121\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}