{"id":231022,"date":"2026-02-10T10:27:56","date_gmt":"2026-02-10T16:27:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-in-a-cohort-of-over-1000-patients-with-breastcancer"},"modified":"2026-02-10T10:27:56","modified_gmt":"2026-02-10T16:27:56","slug":"abstract-in-a-cohort-of-over-1000-patients-with-breastcancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-in-a-cohort-of-over-1000-patients-with-breastcancer","title":{"rendered":"Abstract: In a cohort of over 1,000 patients with BreastCancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract64.jpg\"><\/a><\/p>\n<p>Emilio Hirsch &amp; team identify <i>SH3BP5L<\/i> as the most highly expressed guanine nucleotide exchange factor (GEF) for RAB11A, and its inhibition lowers lung metastasis and cell spreading in triple negative breast cancer models (TNBC):<\/p>\n<p>The figure shows immunohistochemical assessment of <i>SH3BP5L<\/i> expression in tissue from patients with breast cancer.<\/p>\n<p><a href=\"https:\/\/twitter.com\/unito\">@unito<\/a>.it <a href=\"https:\/\/twitter.com\/fondazioneumbertoveronesi\">@fondazioneumbertoveronesi<\/a><\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center \u201cG. Tarone,\u201d University of Torino, Torino, Italy.<\/p>\n<p><sup>2<\/sup>IEO, European Institute of Oncology IRCCS, Milan, Italy.<\/p>\n<p><sup>3<\/sup>Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-in-a-cohort-of-over-1000-patients-with-breastcancer\">Continue reading \u201cAbstract: In a cohort of over 1,000 patients with BreastCancer\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emilio Hirsch &amp; team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor (GEF) for RAB11A, and its inhibition lowers lung metastasis and cell spreading in triple negative breast cancer models (TNBC): The figure shows immunohistochemical assessment of SH3BP5L expression in tissue from patients with breast cancer. @unito.it @fondazioneumbertoveronesi 1Department of Molecular Biotechnology [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,1495],"tags":[],"class_list":["post-231022","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=231022"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/231022\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=231022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=231022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=231022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}