{"id":230981,"date":"2026-02-10T02:39:30","date_gmt":"2026-02-10T08:39:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/deepchopper-model-improves-rna-sequencing-research-by-mitigating-chimera-artifacts"},"modified":"2026-02-10T02:39:30","modified_gmt":"2026-02-10T08:39:30","slug":"deepchopper-model-improves-rna-sequencing-research-by-mitigating-chimera-artifacts","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/deepchopper-model-improves-rna-sequencing-research-by-mitigating-chimera-artifacts","title":{"rendered":"DeepChopper model improves RNA sequencing research by mitigating chimera artifacts"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/deepchopper-model-improves-rna-sequencing-research-by-mitigating-chimera-artifacts2.jpg\"><\/a><\/p>\n<p>Scientists in the laboratory of Rendong Yang, Ph.D., associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-68571-5#Abs1\" target=\"_blank\">published<\/a> in <i>Nature Communications.<\/i><\/p>\n<p>Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.<\/p>\n<p>Among these technologies includes <a href=\"https:\/\/phys.org\/news\/2023-09-nanopore-tech-quicker-mrna-quality.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">nanopore direct RNA sequencing<\/a> (dRNA-seq), which can sequence full-length RNA molecules directly and produce more accurate analyses of RNA biology. However, previous work suggests this approach may generate chimera artifacts\u2014in which multiple RNA sequences incorrectly join to form a single RNA sequence\u2014and limit the reliability and utility of the data.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists in the laboratory of Rendong Yang, Ph.D., associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-230981","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230981"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230981\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}