{"id":230604,"date":"2026-02-05T10:11:59","date_gmt":"2026-02-05T16:11:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/current-treatments-for-gout-are-limited-and-can-have-severe-side-effects"},"modified":"2026-02-05T10:11:59","modified_gmt":"2026-02-05T16:11:59","slug":"current-treatments-for-gout-are-limited-and-can-have-severe-side-effects","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/current-treatments-for-gout-are-limited-and-can-have-severe-side-effects","title":{"rendered":"Current treatments for gout are limited and can have severe side effects"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/current-treatments-for-gout-are-limited-and-can-have-severe-side-effects2.jpg\"><\/a><\/p>\n<p>Here, Lintao Qu &amp; team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation:<\/p>\n<p>The figure: Mouse knee joint sections show treatment with an antibody against neuropeptide substance P (SP) decreases infiltration of neutrophils (Ly6G) and macrophages (CD68) into the synovium (S) in gout arthritis compared with control.<\/p>\n<hr>\n<p>\n<sup>5<\/sup>Department of Endocrinology, Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.<\/p>\n<p><sup>6<\/sup>College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.<\/p>\n<p><sup>7<\/sup>Center of Research Excellence in Allergy and Immunology, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Lintao Qu &amp; team illuminate a neuroimmune mechanism in a mouse gout model involving MRGPRX2 signaling in synovial mast cells that drives pain and joint inflammation: The figure: Mouse knee joint sections show treatment with an antibody against neuropeptide substance P (SP) decreases infiltration of neutrophils (Ly6G) and macrophages (CD68) into the synovium (S) [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230604","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230604"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230604\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}