{"id":230513,"date":"2026-02-04T09:08:04","date_gmt":"2026-02-04T15:08:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-its-about-time-tumor-immune-microenvironment-for-breastcancer"},"modified":"2026-02-04T09:08:04","modified_gmt":"2026-02-04T15:08:04","slug":"abstract-its-about-time-tumor-immune-microenvironment-for-breastcancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/abstract-its-about-time-tumor-immune-microenvironment-for-breastcancer","title":{"rendered":"Abstract: It\u2019s about TIME (tumor immune microenvironment) for BreastCancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract60.jpg\"><\/a><\/p>\n<p>Here, Carlos L. Arteaga &amp; team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via <i>CXCL11<\/i> and immune-related pathways:<\/p>\n<p>The images: GeoMx-based immunofluorescence of breast tumor tissue obtained during estrogen deprivation therapy (letrozole) demonstrates increased immune cell infiltration in estrogen deprivation\u2013resistant tumors (right) compared with sensitive tumors (left).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>UT Southwestern Simmons Comprehensive Cancer Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.<\/p>\n<p><sup>2<\/sup>Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.<\/p>\n<p><sup>3<\/sup>Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Carlos L. Arteaga &amp; team analyze patient biopsies, finding CD8+ T cells in the TIME promote resistance to estrogen suppression in HR+ breast cancer via CXCL11 and immune-related pathways: The images: GeoMx-based immunofluorescence of breast tumor tissue obtained during estrogen deprivation therapy (letrozole) demonstrates increased immune cell infiltration in estrogen deprivation\u2013resistant tumors (right) compared [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230513","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230513"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230513\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}