{"id":230472,"date":"2026-02-03T22:08:41","date_gmt":"2026-02-04T04:08:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/syne1-deficiency-manifesting-primarily-with-motor-neuron-disease"},"modified":"2026-02-03T22:08:41","modified_gmt":"2026-02-04T04:08:41","slug":"syne1-deficiency-manifesting-primarily-with-motor-neuron-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/syne1-deficiency-manifesting-primarily-with-motor-neuron-disease","title":{"rendered":"SYNE1 Deficiency Manifesting Primarily With Motor Neuron Disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/syne1-deficiency-manifesting-primarily-with-motor-neuron-disease2.jpg\"><\/a><\/p>\n<p>Background and ObjectivesSYNE1 deficiency is an autosomal recessive disorder with a broad phenotypic spectrum, most commonly presenting as adult-onset cerebellar ataxia with or without motor neuron dysfunction. We aimed to expand this spectrum by\u2026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background and ObjectivesSYNE1 deficiency is an autosomal recessive disorder with a broad phenotypic spectrum, most commonly presenting as adult-onset cerebellar ataxia with or without motor neuron dysfunction. We aimed to expand this spectrum by\u2026<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-230472","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230472"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230472\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}