{"id":230464,"date":"2026-02-03T17:06:16","date_gmt":"2026-02-03T23:06:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/pancreatic-tumors-eliminated-in-mice-without-resistance-developing"},"modified":"2026-02-03T17:06:16","modified_gmt":"2026-02-03T23:06:16","slug":"pancreatic-tumors-eliminated-in-mice-without-resistance-developing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/pancreatic-tumors-eliminated-in-mice-without-resistance-developing","title":{"rendered":"Pancreatic tumors eliminated in mice without resistance developing"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pancreatic-tumors-eliminated-in-mice-without-resistance-developing2.jpg\"><\/a><\/p>\n<p>Current drugs for pancreatic cancer lose effectiveness within months because the tumor becomes resistant. Now, a group from Spain\u2019s National Cancer Research Centre (CNIO) has been able to avoid the development of resistance in animal models with a combined triple therapy. Mariano Barbacid, head of the Experimental Oncology Group at the CNIO, has designed a therapy that successfully eliminates pancreatic tumors in mice completely and durably, with no significant side effects.<\/p>\n<p>The study is <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2523039122\" target=\"_blank\">published<\/a> in the journal <i>Proceedings of the National Academy of Sciences<\/i>, with Carmen Guerra as co-lead author and Vasiliki Liaki and Sara Barrambana as first authors.<\/p>\n<p>\u201cThese studies open the road to designing novel combination therapies that may improve the survival of PDAC patients [pancreatic ductal adenocarcinoma\u2014the most common type of pancreatic cancer],\u201d the authors state. \u201cThese results set the course for developing new clinical trials.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Current drugs for pancreatic cancer lose effectiveness within months because the tumor becomes resistant. Now, a group from Spain\u2019s National Cancer Research Centre (CNIO) has been able to avoid the development of resistance in animal models with a combined triple therapy. Mariano Barbacid, head of the Experimental Oncology Group at the CNIO, has designed a [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230464","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230464"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230464\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}