{"id":230457,"date":"2026-02-03T14:14:02","date_gmt":"2026-02-03T20:14:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/engineering-immunotherapy-from-within"},"modified":"2026-02-03T14:14:02","modified_gmt":"2026-02-03T20:14:02","slug":"engineering-immunotherapy-from-within","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/engineering-immunotherapy-from-within","title":{"rendered":"Engineering immunotherapy from within"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineering-immunotherapy-from-within2.jpg\"><\/a><\/p>\n<p>In <i>Science<\/i> last year, researchers presented a method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.<\/p>\n<p>The approach showed rapid and sustained immune reprogramming in preclinical models, highlighting its promise for treating cancer and autoimmune diseases.<\/p>\n<p>Learn more on WorldCancerDay.<\/p>\n<hr>\n<p>Lipid nanoparticles are designed to generate therapeutic T cells inside living animal models.<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ady7928#con1\"> Vivek Peche<\/a> and <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ady7928#con2\"> Stephen Gottschalk<\/a> <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ady7928#tab-contributors\">Authors Info &amp; Affiliations<\/a><\/p>\n<p><i>Science<\/i><\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/02\/engineering-immunotherapy-from-within\">Continue reading \u201cEngineering immunotherapy from within\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In Science last year, researchers presented a method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. The approach showed rapid and sustained immune reprogramming in preclinical models, highlighting its promise for treating cancer and autoimmune diseases. Learn more on WorldCancerDay. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,38,4],"tags":[],"class_list":["post-230457","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-engineering","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230457"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230457\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}