{"id":230421,"date":"2026-02-03T01:44:28","date_gmt":"2026-02-03T07:44:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/trpv4-skeletal-disorders-are-currently-treated-by-bracing-and-with-surgery"},"modified":"2026-02-03T01:44:28","modified_gmt":"2026-02-03T07:44:28","slug":"trpv4-skeletal-disorders-are-currently-treated-by-bracing-and-with-surgery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/trpv4-skeletal-disorders-are-currently-treated-by-bracing-and-with-surgery","title":{"rendered":"TRPV4 skeletal disorders are currently treated by bracing and with surgery\u2014"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/trpv4-skeletal-disorders-are-currently-treated-by-bracing-and-with-surgery2.jpg\"><\/a><\/p>\n<p>No pharmacologic therapies are available.<\/p>\n<p>Here, Daniel H Cohn &amp; team rescue the skeletal dysplasia phenotype of Trpv4 mutant mice\u2014a new mouse model\u2014using small molecule inhibition:<\/p>\n<p>The figure: Reconstructed micro-CT images from WT and <i>Co2a1-Cre<\/i>\/Trpv4p. R59H mutant mice showing reduction in the cervical angle (dashed red lines). The T1 vertebral body in the mutant was smaller and poorly mineralized.<\/p>\n<hr>\n<p>\n<sup>2<\/sup>Actio Biosciences, San Diego, California, USA.<\/p>\n<p><sup>3<\/sup>Department of Orthopaedic Surgery, UCLA, Los Angeles, California, USA.<\/p>\n<p><sup>4<\/sup>Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Dell Medical School, Austin, Texas, USA.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/02\/trpv4-skeletal-disorders-are-currently-treated-by-bracing-and-with-surgery\">Continue reading \u201cTRPV4 skeletal disorders are currently treated by bracing and with surgery\u2014\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>No pharmacologic therapies are available. Here, Daniel H Cohn &amp; team rescue the skeletal dysplasia phenotype of Trpv4 mutant mice\u2014a new mouse model\u2014using small molecule inhibition: The figure: Reconstructed micro-CT images from WT and Co2a1-Cre\/Trpv4p. R59H mutant mice showing reduction in the cervical angle (dashed red lines). The T1 vertebral body in the mutant was [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230421","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230421"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230421\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}