{"id":230368,"date":"2026-02-02T21:12:53","date_gmt":"2026-02-03T03:12:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/cancer-associated-fibroblast-derived-extracellular-vesicles-deliver-atp6v1c1-to-promote-lung-adenocarcinoma-metastasis-via-the-id1-igfbp3-axis"},"modified":"2026-02-02T21:12:53","modified_gmt":"2026-02-03T03:12:53","slug":"cancer-associated-fibroblast-derived-extracellular-vesicles-deliver-atp6v1c1-to-promote-lung-adenocarcinoma-metastasis-via-the-id1-igfbp3-axis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/cancer-associated-fibroblast-derived-extracellular-vesicles-deliver-atp6v1c1-to-promote-lung-adenocarcinoma-metastasis-via-the-id1-igfbp3-axis","title":{"rendered":"Cancer-associated fibroblast-derived extracellular vesicles deliver ATP6V1C1 to promote lung adenocarcinoma metastasis via the ID1-IGFBP3 axis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cancer-associated-fibroblast-derived-extracellular-vesicles-deliver-atp6v1c1-to-promote-lung-adenocarcinoma-metastasis-via-the-id1-igfbp3-axis2.jpg\"><\/a><\/p>\n<p>Chen et al. reveal the V-ATPase subunit <i>ATP6V1C1<\/i> as a non-canonical transcriptional repressor delivered by CAF-derived EVs to drive LUAD metastasis. By suppressing <i>IGFBP3<\/i>, <i>ATP6V1C1<\/i> simultaneously triggers EMT and amplifies stromal IGF1 signaling, creating a potent pro-metastatic feedforward loop.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chen et al. reveal the V-ATPase subunit ATP6V1C1 as a non-canonical transcriptional repressor delivered by CAF-derived EVs to drive LUAD metastasis. By suppressing IGFBP3, ATP6V1C1 simultaneously triggers EMT and amplifies stromal IGF1 signaling, creating a potent pro-metastatic feedforward loop.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230368","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230368"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230368\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}