{"id":230299,"date":"2026-02-01T13:08:40","date_gmt":"2026-02-01T19:08:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/uncovering-genetic-interactions-in-the-dna-repair-network-in-response-to-endogenous-damage-and-ionizing-radiation"},"modified":"2026-02-01T13:08:40","modified_gmt":"2026-02-01T19:08:40","slug":"uncovering-genetic-interactions-in-the-dna-repair-network-in-response-to-endogenous-damage-and-ionizing-radiation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/uncovering-genetic-interactions-in-the-dna-repair-network-in-response-to-endogenous-damage-and-ionizing-radiation","title":{"rendered":"Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/uncovering-genetic-interactions-in-the-dna-repair-network-in-response-to-endogenous-damage-and-ionizing-radiation2.jpg\"><\/a><\/p>\n<p>Nebenfuehr et al. perform a combinatorial CRISPR-Cas9 screen targeting 461 DNA damage response genes under basal and irradiated conditions. The study maps thousands of genetic interactions, generating a rich resource to uncover mechanisms of genome maintenance and inspire future studies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nebenfuehr et al. perform a combinatorial CRISPR-Cas9 screen targeting 461 DNA damage response genes under basal and irradiated conditions. The study maps thousands of genetic interactions, generating a rich resource to uncover mechanisms of genome maintenance and inspire future studies.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-230299","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230299"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230299\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}