{"id":230294,"date":"2026-02-01T10:04:41","date_gmt":"2026-02-01T16:04:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/02\/crispr-screens-in-ipsc-derived-neurons-reveal-principles-of-tau-proteostasis"},"modified":"2026-02-01T10:04:41","modified_gmt":"2026-02-01T16:04:41","slug":"crispr-screens-in-ipsc-derived-neurons-reveal-principles-of-tau-proteostasis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/02\/crispr-screens-in-ipsc-derived-neurons-reveal-principles-of-tau-proteostasis","title":{"rendered":"CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispr-screens-in-ipsc-derived-neurons-reveal-principles-of-tau-proteostasis2.jpg\"><\/a><\/p>\n<p>Now online! CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer\u2019s disease, and that electron transport chain dysfunction alters tau degradation by the proteasome.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer\u2019s disease, and that electron transport chain dysfunction alters tau degradation by the proteasome.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-230294","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230294"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230294\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}