{"id":230161,"date":"2026-01-30T10:12:49","date_gmt":"2026-01-30T16:12:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/abstract-the-optimal-affinity-of-the-chimeric-antigen-receptor-for-its-target-antigen-on-cancer-cells-remains-a-matter-of-debate"},"modified":"2026-01-30T10:12:49","modified_gmt":"2026-01-30T16:12:49","slug":"abstract-the-optimal-affinity-of-the-chimeric-antigen-receptor-for-its-target-antigen-on-cancer-cells-remains-a-matter-of-debate","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/abstract-the-optimal-affinity-of-the-chimeric-antigen-receptor-for-its-target-antigen-on-cancer-cells-remains-a-matter-of-debate","title":{"rendered":"Abstract: The optimal affinity of the chimeric antigen receptor for its target antigen on cancer cells remains a matter of debate"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract57.jpg\"><\/a><\/p>\n<p>Here, Bert Vogelstein &amp; team report that increasing binding affinity to a p53 R175H neoantigen improves anti-cancer activity for T cell-engaging bispecific antibodies and conversely decreases function for CAR T cells.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<\/p>\n<p><sup>2<\/sup>Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.<\/p>\n<p><sup>3<\/sup>Lustgarten Pancreatic <i>Cancer Res<\/i>earch Laboratory and.<\/p>\n<p><sup>4<\/sup>Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Bert Vogelstein &amp; team report that increasing binding affinity to a p53 R175H neoantigen improves anti-cancer activity for T cell-engaging bispecific antibodies and conversely decreases function for CAR T cells. 1Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 2Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230161","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230161"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230161\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}