{"id":230149,"date":"2026-01-30T01:27:19","date_gmt":"2026-01-30T07:27:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/dual-targeting-of-slc25a51-and-succinate-dehydrogenase-selectively-depletes-mitochondrial-nad-to-eradicate-kras-driven-aml"},"modified":"2026-01-30T01:27:19","modified_gmt":"2026-01-30T07:27:19","slug":"dual-targeting-of-slc25a51-and-succinate-dehydrogenase-selectively-depletes-mitochondrial-nad-to-eradicate-kras-driven-aml","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/dual-targeting-of-slc25a51-and-succinate-dehydrogenase-selectively-depletes-mitochondrial-nad-to-eradicate-kras-driven-aml","title":{"rendered":"Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dual-targeting-of-slc25a51-and-succinate-dehydrogenase-selectively-depletes-mitochondrial-nad-to-eradicate-kras-driven-aml2.jpg\"><\/a><\/p>\n<p>Online now: Jia et al. reveal that KRAS-mutant leukemic cells, which express low SLC25A51 protein, are selectively killed by 615 through reducing mitochondrial NAD+. 615 simultaneously binds to and inhibits both SLC25A51, a mitochondrial NAD+ importer, and SDHA, an ETC component. It further reduces SLC25A51 protein by decreasing K264 succinylation, thereby depleting mitochondrial NAD+.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: Jia et al. reveal that KRAS-mutant leukemic cells, which express low SLC25A51 protein, are selectively killed by 615 through reducing mitochondrial NAD+. 615 simultaneously binds to and inhibits both SLC25A51, a mitochondrial NAD+ importer, and SDHA, an ETC component. It further reduces SLC25A51 protein by decreasing K264 succinylation, thereby depleting mitochondrial NAD+.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230149","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230149"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230149\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}