{"id":230083,"date":"2026-01-29T09:16:43","date_gmt":"2026-01-29T15:16:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/the-cytokine-tnf-is-a-driver-of-rheumatoid-arthritis-but-the-signaling-pathway-details-remain-incomplete"},"modified":"2026-01-29T09:16:43","modified_gmt":"2026-01-29T15:16:43","slug":"the-cytokine-tnf-is-a-driver-of-rheumatoid-arthritis-but-the-signaling-pathway-details-remain-incomplete","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/the-cytokine-tnf-is-a-driver-of-rheumatoid-arthritis-but-the-signaling-pathway-details-remain-incomplete","title":{"rendered":"The cytokine TNF is a driver of rheumatoid arthritis, but the signaling-pathway details remain incomplete"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-cytokine-tnf-is-a-driver-of-rheumatoid-arthritis-but-the-signaling-pathway-details-remain-incomplete2.jpg\"><\/a><\/p>\n<p>Here, Sarah Gaffen &amp; team report on the noncanonical RNA binding protein <i>Arid5a<\/i> as an activator of TNF signaling that is elevated in human RA tissues. And in mice\u2026 its loss results in resistance to collagen-induced arthritis:<\/p>\n<p>The figure shows TNF stimulation causes <i>Arid5a<\/i> accumulation in the cytoplasm in a murine stromal fibroblast cell line untreated (left) and treated (right); <i>Arid5a<\/i> (red); RPL7A (green); nuclei (blue).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Division of Rheumatology &amp; Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<\/p>\n<p><sup>2<\/sup>BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.<\/p>\n<p><sup>3<\/sup>School of Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Sarah Gaffen &amp; team report on the noncanonical RNA binding protein Arid5a as an activator of TNF signaling that is elevated in human RA tissues. And in mice\u2026 its loss results in resistance to collagen-induced arthritis: The figure shows TNF stimulation causes Arid5a accumulation in the cytoplasm in a murine stromal fibroblast cell line [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-230083","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=230083"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/230083\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=230083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=230083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=230083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}