{"id":229966,"date":"2026-01-28T01:39:26","date_gmt":"2026-01-28T07:39:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/ferroplasticity-drives-social-isolation-induced-anxiety-via-a-ventral-hippocampal-iron-%ce%b1-synuclein-axis"},"modified":"2026-01-28T01:39:26","modified_gmt":"2026-01-28T07:39:26","slug":"ferroplasticity-drives-social-isolation-induced-anxiety-via-a-ventral-hippocampal-iron-%ce%b1-synuclein-axis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/ferroplasticity-drives-social-isolation-induced-anxiety-via-a-ventral-hippocampal-iron-%ce%b1-synuclein-axis","title":{"rendered":"Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-\u03b1-synuclein axis"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ferroplasticity-drives-social-isolation-induced-anxiety-via-a-ventral-hippocampal-iron-ceb1-synuclein-axis.jpg\"><\/a><\/p>\n<p>Online now: Social isolation is a major risk factor for anxiety disorders. Wang et al. reveal that isolation of mice drives anxiety through an iron-dependent synaptic remodeling mechanism (ferroplasticity) in the ventral hippocampus. Targeting excess brain iron or \u03b1-synuclein signaling via non-invasive intranasal delivery rescues anxiety, offering a novel therapeutic strategy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: Social isolation is a major risk factor for anxiety disorders. Wang et al. reveal that isolation of mice drives anxiety through an iron-dependent synaptic remodeling mechanism (ferroplasticity) in the ventral hippocampus. Targeting excess brain iron or \u03b1-synuclein signaling via non-invasive intranasal delivery rescues anxiety, offering a novel therapeutic strategy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-229966","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229966"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229966\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}