{"id":229838,"date":"2026-01-26T17:16:18","date_gmt":"2026-01-26T23:16:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/what-are-the-roles-of-mitochondrial-stress-responses-and-mitohormesis-in-neurodegenerative-disorders"},"modified":"2026-01-26T17:16:18","modified_gmt":"2026-01-26T23:16:18","slug":"what-are-the-roles-of-mitochondrial-stress-responses-and-mitohormesis-in-neurodegenerative-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/what-are-the-roles-of-mitochondrial-stress-responses-and-mitohormesis-in-neurodegenerative-disorders","title":{"rendered":"What Are the Roles of Mitochondrial Stress Responses and Mitohormesis in Neurodegenerative Disorders?"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/what-are-the-roles-of-mitochondrial-stress-responses-and-mitohormesis-in-neurodegenerative-disorders.jpg\"><\/a><\/p>\n<p>Structure basis for the activation of KCNQ2 by endogenous and exogenous ligands.<\/p>\n<hr>\n<p>Zhao et al. report cryo-EM structures of human KCNQ2 in complex with QO-58 and QO-83 in multiple conformations, with or without PIP2. Together with electrophysiological and computational analyses, these structures provide insight into the channel\u2019s activation mechanism and support the rational design of targeted anti-epileptic therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Structure basis for the activation of KCNQ2 by endogenous and exogenous ligands. Zhao et al. report cryo-EM structures of human KCNQ2 in complex with QO-58 and QO-83 in multiple conformations, with or without PIP2. Together with electrophysiological and computational analyses, these structures provide insight into the channel\u2019s activation mechanism and support the rational design of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,47],"tags":[],"class_list":["post-229838","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229838"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229838\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}