{"id":229796,"date":"2026-01-25T22:13:49","date_gmt":"2026-01-26T04:13:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/contaminating-plasmid-sequences-and-disrupted-vector-genomes-in-the-liver-following-adeno-associated-virus-gene-therapy"},"modified":"2026-01-25T22:13:49","modified_gmt":"2026-01-26T04:13:49","slug":"contaminating-plasmid-sequences-and-disrupted-vector-genomes-in-the-liver-following-adeno-associated-virus-gene-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/contaminating-plasmid-sequences-and-disrupted-vector-genomes-in-the-liver-following-adeno-associated-virus-gene-therapy","title":{"rendered":"Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/contaminating-plasmid-sequences-and-disrupted-vector-genomes-in-the-liver-following-adeno-associated-virus-gene-therapy.jpg\"><\/a><\/p>\n<p>A valuable paper examining the presence of AAV manufacturing contaminants in a human patient\u2019s liver. These results will hopefully be leveraged for improving the safety of gene therapies in the future.<\/p>\n<hr>\n<p>Analyses of liver biopsies from a child with spinal muscular atrophy treated with adeno-associated virus gene therapy who developed hepatitis reveal contaminating manufacturing plasmids and disrupted vector genomes, possibly resulting from recombination events.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A valuable paper examining the presence of AAV manufacturing contaminants in a human patient\u2019s liver. These results will hopefully be leveraged for improving the safety of gene therapies in the future. Analyses of liver biopsies from a child with spinal muscular atrophy treated with adeno-associated virus gene therapy who developed hepatitis reveal contaminating manufacturing plasmids [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,20],"tags":[],"class_list":["post-229796","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229796"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229796\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}