{"id":229793,"date":"2026-01-25T22:09:22","date_gmt":"2026-01-26T04:09:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/widespread-liver-dysfunction-in-down-syndrome"},"modified":"2026-01-25T22:09:22","modified_gmt":"2026-01-26T04:09:22","slug":"widespread-liver-dysfunction-in-down-syndrome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/widespread-liver-dysfunction-in-down-syndrome","title":{"rendered":"Widespread liver dysfunction in Down syndrome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/widespread-liver-dysfunction-in-down-syndrome2.jpg\"><\/a><\/p>\n<p>Patients with detectable virus-specific T cells before checkpoint inhibitor therapy in PML demonstrated better survival rates and functional recovery than those without.<\/p>\n<hr>\n<p>Question Are pretreatment JC virus-and\/or BK virus-specific T cells in the blood associated with the efficacy of immune checkpoint inhibitors (ICIs) in progressive multifocal leukoencephalopathy (PML)?<\/p>\n<p><strong>Findings<\/strong> In this cohort study of 111 patients with PML treated with ICIs, those with detectable virus-specific T cells (n = 21) had significantly higher response rates and longer survival than both T cell\u2013negative patients (n = 22) and those with unknown status (n = 68).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patients with detectable virus-specific T cells before checkpoint inhibitor therapy in PML demonstrated better survival rates and functional recovery than those without. Question Are pretreatment JC virus-and\/or BK virus-specific T cells in the blood associated with the efficacy of immune checkpoint inhibitors (ICIs) in progressive multifocal leukoencephalopathy (PML)? Findings In this cohort study of 111 [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-229793","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229793"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229793\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}