{"id":229763,"date":"2026-01-24T21:16:58","date_gmt":"2026-01-25T03:16:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/peripheral-cancer-attenuates-amyloid-pathology-in-alzheimers-disease-via-cystatin-c-activation-of-trem2"},"modified":"2026-01-24T21:16:58","modified_gmt":"2026-01-25T03:16:58","slug":"peripheral-cancer-attenuates-amyloid-pathology-in-alzheimers-disease-via-cystatin-c-activation-of-trem2","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/peripheral-cancer-attenuates-amyloid-pathology-in-alzheimers-disease-via-cystatin-c-activation-of-trem2","title":{"rendered":"Peripheral cancer attenuates amyloid pathology in Alzheimer\u2019s disease via cystatin-c activation of TREM2"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/peripheral-cancer-attenuates-amyloid-pathology-in-alzheimers-disease-via-cystatin-c-activation-of-trem22.jpg\"><\/a><\/p>\n<p>Now online! Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer\u2019s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and enables microglia to degrade pre-existing plaques.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer\u2019s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and enables microglia to degrade pre-existing plaques.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-229763","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229763","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229763"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229763\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}