{"id":229667,"date":"2026-01-23T14:14:33","date_gmt":"2026-01-23T20:14:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/a-viable-therapeutic-target-pancreatic-ductal-adenocarcinoma"},"modified":"2026-01-23T14:14:33","modified_gmt":"2026-01-23T20:14:33","slug":"a-viable-therapeutic-target-pancreatic-ductal-adenocarcinoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/a-viable-therapeutic-target-pancreatic-ductal-adenocarcinoma","title":{"rendered":"A viable therapeutic target pancreatic ductal adenocarcinoma"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-viable-therapeutic-target-pancreatic-ductal-adenocarcinoma.jpg\"><\/a><\/p>\n<p>This issue\u2019s cover features work by Adrian M. Seifert &amp; team on Nectin-4\u2019s connection to poor outcome and immune suppression in patients with PDAC, and targeting Nectin-4 with the antibody-drug conjugate enfortumab vedotin inhibited tumor growth in PDAC organoids:<\/p>\n<p>The cover image shows high Nectin-4 immunohistochemistry staining (brown) in human PDAC.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany.<\/p>\n<p><sup>2<\/sup>National Center for Tumor Diseases (NCT), Dresden, Germany.<\/p>\n<p><sup>3<\/sup>German <i>Cancer Res<\/i>earch Center (DKFZ), Heidelberg, Germany.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This issue\u2019s cover features work by Adrian M. Seifert &amp; team on Nectin-4\u2019s connection to poor outcome and immune suppression in patients with PDAC, and targeting Nectin-4 with the antibody-drug conjugate enfortumab vedotin inhibited tumor growth in PDAC organoids: The cover image shows high Nectin-4 immunohistochemistry staining (brown) in human PDAC. 1Department of Visceral, Thoracic [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-229667","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229667"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229667\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}