{"id":229599,"date":"2026-01-22T13:06:59","date_gmt":"2026-01-22T19:06:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/cellular-senescence-linked-to-brain-structure-changes-across-lifespan"},"modified":"2026-01-22T13:06:59","modified_gmt":"2026-01-22T19:06:59","slug":"cellular-senescence-linked-to-brain-structure-changes-across-lifespan","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/cellular-senescence-linked-to-brain-structure-changes-across-lifespan","title":{"rendered":"Cellular senescence linked to brain structure changes across lifespan"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cellular-senescence-linked-to-brain-structure-changes-across-lifespan.jpg\"><\/a><\/p>\n<p>Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence\u2014a biological process in which aging cells change how they function\u2014is associated with human brain structure in both development and late life.<\/p>\n<p>The study, <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01179-1\" target=\"_blank\">published<\/a> in <i>Cell<\/i>, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.<\/p>\n<p>Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson\u2019s and Alzheimer\u2019s diseases, the underlying molecular processes involved\u2014including cellular senescence\u2014are not defined.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence\u2014a biological process in which aging cells change how they function\u2014is associated with human brain structure in both development and late life. The study, published in Cell, provides new insight into how molecular signatures of cellular senescence that are present during [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-229599","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229599"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229599\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}