{"id":229529,"date":"2026-01-21T21:26:47","date_gmt":"2026-01-22T03:26:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/low-input-proteomics-identifies-vwf-as-a-negative-regulator-of-tet2-mutant-hematopoietic-stem-cell-expansion"},"modified":"2026-01-21T21:26:47","modified_gmt":"2026-01-22T03:26:47","slug":"low-input-proteomics-identifies-vwf-as-a-negative-regulator-of-tet2-mutant-hematopoietic-stem-cell-expansion","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/low-input-proteomics-identifies-vwf-as-a-negative-regulator-of-tet2-mutant-hematopoietic-stem-cell-expansion","title":{"rendered":"Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/low-input-proteomics-identifies-vwf-as-a-negative-regulator-of-tet2-mutant-hematopoietic-stem-cell-expansion.jpg\"><\/a><\/p>\n<p>Jassinskaja, Bode et al. provide a multi-omics characterization of Tet2-mutated cells, including global proteomics revealing novel roles for extracellular matrix (ECM) molecules in selectively modifying self-renewal divisions. These findings point more broadly to physical and mechanical mediators of self-renewal, implicating integrins and cytokine signaling as extracellular drivers of clonal expansion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jassinskaja, Bode et al. provide a multi-omics characterization of Tet2-mutated cells, including global proteomics revealing novel roles for extracellular matrix (ECM) molecules in selectively modifying self-renewal divisions. These findings point more broadly to physical and mechanical mediators of self-renewal, implicating integrins and cytokine signaling as extracellular drivers of clonal expansion.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-229529","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229529"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229529\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}