{"id":229432,"date":"2026-01-20T21:10:50","date_gmt":"2026-01-21T03:10:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/b-cells-play-a-more-sinister-role-than-believed-in-progression-of-type-1-diabetes"},"modified":"2026-01-20T21:10:50","modified_gmt":"2026-01-21T03:10:50","slug":"b-cells-play-a-more-sinister-role-than-believed-in-progression-of-type-1-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/b-cells-play-a-more-sinister-role-than-believed-in-progression-of-type-1-diabetes","title":{"rendered":"B cells play a more sinister role than believed in progression of type 1 diabetes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/b-cells-play-a-more-sinister-role-than-believed-in-progression-of-type-1-diabetes2.jpg\"><\/a><\/p>\n<p>A recent study by Vanderbilt Health researchers has revealed a greater, detrimental role for B lymphocytes (B cells) in the progression of type 1 diabetes (T1D).<\/p>\n<p>B cells are immune cells thought to drive the immune system\u2019s attack on insulin-producing beta cells by activating anti-islet T cells. The study <a href=\"https:\/\/diabetesjournals.org\/diabetes\/article\/doi\/10.2337\/db25-0241\/163906\/B-Lymphocytes-Impede-Tregs-to-Erode-Islet\" target=\"_blank\">published<\/a> in <i>Diabetes<\/i> suggests they play an even more sinister role by also interfering with and limiting the function of <a href=\"https:\/\/medicalxpress.com\/news\/2023-12-diabetes-cell-derived-natural-antibodies-suppress.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">regulatory T cells<\/a> (Tregs) that help calm the immune system.<\/p>\n<p>\u201cOur study showed B cells can weaken the body\u2019s natural defenses by interfering with Tregs, which normally behave as peacekeepers to ward off immune attacks on the pancreas and the insulin-producing beta cells,\u201d said Daniel Moore, MD, PhD, associate professor of Pediatrics at Vanderbilt Health and the study\u2019s corresponding author.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study by Vanderbilt Health researchers has revealed a greater, detrimental role for B lymphocytes (B cells) in the progression of type 1 diabetes (T1D). B cells are immune cells thought to drive the immune system\u2019s attack on insulin-producing beta cells by activating anti-islet T cells. The study published in Diabetes suggests they play [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-229432","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229432"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229432\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}