{"id":229341,"date":"2026-01-19T22:16:20","date_gmt":"2026-01-20T04:16:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/intermittent-hypobaric-pressure-induces-selective-senescent-cell-death-and-alleviates-age-related-osteoporosis"},"modified":"2026-01-19T22:16:20","modified_gmt":"2026-01-20T04:16:20","slug":"intermittent-hypobaric-pressure-induces-selective-senescent-cell-death-and-alleviates-age-related-osteoporosis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/intermittent-hypobaric-pressure-induces-selective-senescent-cell-death-and-alleviates-age-related-osteoporosis","title":{"rendered":"Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/intermittent-hypobaric-pressure-induces-selective-senescent-cell-death-and-alleviates-age-related-osteoporosis2.jpg\"><\/a><\/p>\n<p>Intermittent hypobaric pressure extends the lifespan and rescues the osteoporosis phenotype in aged mice by activating the ion channel transmembrane protein 59 (TMEM59) and eliminating senescent cells via lysosome-dependent cell death.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intermittent hypobaric pressure extends the lifespan and rescues the osteoporosis phenotype in aged mice by activating the ion channel transmembrane protein 59 (TMEM59) and eliminating senescent cells via lysosome-dependent cell death.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-229341","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229341"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229341\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}