{"id":229234,"date":"2026-01-17T13:09:16","date_gmt":"2026-01-17T19:09:16","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/igg2c-subclass-dominance-drives-fatal-lupus-like-nephritis-via-fc%ce%b3r-and-complement-activation"},"modified":"2026-01-17T13:09:16","modified_gmt":"2026-01-17T19:09:16","slug":"igg2c-subclass-dominance-drives-fatal-lupus-like-nephritis-via-fc%ce%b3r-and-complement-activation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/igg2c-subclass-dominance-drives-fatal-lupus-like-nephritis-via-fc%ce%b3r-and-complement-activation","title":{"rendered":"IgG2c subclass dominance drives fatal lupus-like nephritis via Fc\u03b3R and complement activation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/igg2c-subclass-dominance-drives-fatal-lupus-like-nephritis-via-fcceb3r-and-complement-activation2.jpg\"><\/a><\/p>\n<p>Luan et al. establish the first mouse model that develops spontaneous, fully penetrant, and rapid-onset glomerulonephritis, demonstrating that dominant expression of an activating IgG subclass is sufficient to drive lethal lupus-like nephritis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Luan et al. establish the first mouse model that develops spontaneous, fully penetrant, and rapid-onset glomerulonephritis, demonstrating that dominant expression of an activating IgG subclass is sufficient to drive lethal lupus-like nephritis.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-229234","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229234"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229234\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}