{"id":229226,"date":"2026-01-17T02:26:40","date_gmt":"2026-01-17T08:26:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/mitochondrial-dna%e2%80%90mediated-immune-activation-after-resuscitation-from-cardiac-arrest"},"modified":"2026-01-17T02:26:40","modified_gmt":"2026-01-17T08:26:40","slug":"mitochondrial-dna%e2%80%90mediated-immune-activation-after-resuscitation-from-cardiac-arrest","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/mitochondrial-dna%e2%80%90mediated-immune-activation-after-resuscitation-from-cardiac-arrest","title":{"rendered":"Mitochondrial DNA\u2010Mediated Immune Activation After Resuscitation From Cardiac Arrest"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mitochondrial-dnae28090mediated-immune-activation-after-resuscitation-from-cardiac-arrest2.jpg\"><\/a><\/p>\n<p>EV\u2010encapsulated mtDNA activates immune cells after cardiac arrest, revealing new targets to modulate post-resuscitation inflammation. <a href=\"https:\/\/twitter.com\/UBuffalo\">@UBuffalo<\/a> <a href=\"https:\/\/twitter.com\/Jacobs_Med_UB\">@Jacobs_Med_UB<\/a><\/p>\n<hr>\n<p>BackgroundPostcardiac arrest syndrome is characterized by systemic inflammation that contributes to poor outcomes after resuscitation from sudden cardiac arrest. Mitochondrial DNA (mtDNA) has been implicated as a proinflammatory stimulus in other contexts, but its role in postcardiac arrest syndrome is unclear. We determined if postcardiac arrest syndrome is characterized by a rise in circulating mtDNA, how mtDNA activates immune cells, and if targeting mtDNA\u2010sensing pathways attenuates leukocyte activation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EV\u2010encapsulated mtDNA activates immune cells after cardiac arrest, revealing new targets to modulate post-resuscitation inflammation. @UBuffalo @Jacobs_Med_UB BackgroundPostcardiac arrest syndrome is characterized by systemic inflammation that contributes to poor outcomes after resuscitation from sudden cardiac arrest. Mitochondrial DNA (mtDNA) has been implicated as a proinflammatory stimulus in other contexts, but its role in postcardiac arrest [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-229226","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229226"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229226\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}