{"id":229162,"date":"2026-01-16T09:19:54","date_gmt":"2026-01-16T15:19:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/an-il-12-partial-agonist-sustains-intratumoral-lymphocyte-activation-and-detoxifies-systemic-il-12-therapy"},"modified":"2026-01-16T09:19:54","modified_gmt":"2026-01-16T15:19:54","slug":"an-il-12-partial-agonist-sustains-intratumoral-lymphocyte-activation-and-detoxifies-systemic-il-12-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/an-il-12-partial-agonist-sustains-intratumoral-lymphocyte-activation-and-detoxifies-systemic-il-12-therapy","title":{"rendered":"An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/an-il-12-partial-agonist-sustains-intratumoral-lymphocyte-activation-and-detoxifies-systemic-il-12-therapy2.jpg\"><\/a><\/p>\n<p>IL-12 is a promising tumor immunotherapy, but its therapeutic use is limited by acute NK cell-associated toxicity. Koliesnik et al. report the discovery of STK-026, an IL-12-Fc partial agonist that preferentially drives effector function in T cells, which express high levels of IL-12 receptors, and avoids NK cell-associated toxicity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>IL-12 is a promising tumor immunotherapy, but its therapeutic use is limited by acute NK cell-associated toxicity. Koliesnik et al. report the discovery of STK-026, an IL-12-Fc partial agonist that preferentially drives effector function in T cells, which express high levels of IL-12 receptors, and avoids NK cell-associated toxicity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-229162","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=229162"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/229162\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=229162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=229162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=229162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}