{"id":228941,"date":"2026-01-13T13:23:26","date_gmt":"2026-01-13T19:23:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans"},"modified":"2026-01-13T13:23:26","modified_gmt":"2026-01-13T19:23:26","slug":"age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans","title":{"rendered":"Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/age-independent-and-targetable-transcription-factor-networks-regulating-cd8-t-cell-senescence-in-aging-humans2.jpg\"><\/a><\/p>\n<p>Turano et al. reveal the transcription factor networks driving CD8+ T cell senescence in healthy aging humans. Inhibiting key transcription factors modulates the senescence program and partially restores responsiveness to TCR stimulation. They also show that CD8+ T cell senescence gene signatures predict response to CAR-T cell therapy in B cell lymphomas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Turano et al. reveal the transcription factor networks driving CD8+ T cell senescence in healthy aging humans. Inhibiting key transcription factors modulates the senescence program and partially restores responsiveness to TCR stimulation. They also show that CD8+ T cell senescence gene signatures predict response to CAR-T cell therapy in B cell lymphomas.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-228941","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228941"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228941\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}