{"id":228883,"date":"2026-01-13T01:23:31","date_gmt":"2026-01-13T07:23:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/two-wrongs-make-a-right-how-two-damaging-disease-variants-can-restore-health"},"modified":"2026-01-13T01:23:31","modified_gmt":"2026-01-13T07:23:31","slug":"two-wrongs-make-a-right-how-two-damaging-disease-variants-can-restore-health","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/two-wrongs-make-a-right-how-two-damaging-disease-variants-can-restore-health","title":{"rendered":"Two wrongs make a right: How two damaging disease variants can restore health"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/two-wrongs-make-a-right-how-two-damaging-disease-variants-can-restore-health.jpg\"><\/a><\/p>\n<p>Scientists at Pacific Northwest Research Institute (PNRI) have overturned a long-held belief in genetics: that inheriting two harmful variants of the same gene always worsens disease. Instead, the team found that in many cases, two harmful variants can actually restore normal protein function.<\/p>\n<p>Their work appears in the Proceedings of the National Academy of Sciences.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at Pacific Northwest Research Institute (PNRI) have overturned a long-held belief in genetics: that inheriting two harmful variants of the same gene always worsens disease. Instead, the team found that in many cases, two harmful variants can actually restore normal protein function. Their work appears in the Proceedings of the National Academy of Sciences.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-228883","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228883"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228883\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}