{"id":228872,"date":"2026-01-12T21:16:28","date_gmt":"2026-01-13T03:16:28","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/autologous-t-cell-therapy-targeting-multiple-antigens-shows-promise-in-treating-pancreatic-cancer"},"modified":"2026-01-12T21:16:28","modified_gmt":"2026-01-13T03:16:28","slug":"autologous-t-cell-therapy-targeting-multiple-antigens-shows-promise-in-treating-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/autologous-t-cell-therapy-targeting-multiple-antigens-shows-promise-in-treating-pancreatic-cancer","title":{"rendered":"Autologous T cell therapy targeting multiple antigens shows promise in treating pancreatic cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/logo.autologous-t-cell-therapy-targeting-multiple-antigens-shows-promise-in-treating-pancreatic-cancer2.jpg\"><\/a><\/p>\n<p>A recent publication in <i>Nature Medicine<\/i> <a href=\"https:\/\/www.nature.com\/articles\/s41591-025-04043-5\" target=\"_blank\">describes<\/a> a novel immunotherapy targeting pancreatic cancer that has shown promising results in a first in-human phase 1\/2 trial.<\/p>\n<p>The <a href=\"https:\/\/medicalxpress.com\/news\/2026-01-free-atlas-immunotherapy-responses-pancreatic.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">TACTOPS trial<\/a>, which investigated the safety and clinical effects of autologous T cell therapy targeting multiple tumor antigens, was a collaboration among researchers at Baylor College of Medicine, the Dan L Duncan Comprehensive Cancer Center, the Center for Cell and Gene Therapy, Texas Children\u2019s Hospital and Houston Methodist Hospital.<\/p>\n<p>\u201cWe wanted to develop a <a href=\"https:\/\/medicalxpress.com\/news\/2022-06-genetic-tough-to-treat-cancer.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">targeted therapeutic<\/a> that would hone the immune system on tumor-associated antigens (TAAs) that were present on malignant cells. We targeted five different antigens to deal with the polyclonal nature of the disease,\u201d said co-corresponding author Dr. Ann Leen, professor of pediatrics\u2013hematology and oncology in the Center for Cell and Gene Therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent publication in Nature Medicine describes a novel immunotherapy targeting pancreatic cancer that has shown promising results in a first in-human phase 1\/2 trial. The TACTOPS trial, which investigated the safety and clinical effects of autologous T cell therapy targeting multiple tumor antigens, was a collaboration among researchers at Baylor College of Medicine, the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-228872","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228872"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228872\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}