{"id":228855,"date":"2026-01-12T17:04:34","date_gmt":"2026-01-12T23:04:34","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/this-years-biggest-breakthroughs-in-longevity"},"modified":"2026-01-12T17:04:34","modified_gmt":"2026-01-12T23:04:34","slug":"this-years-biggest-breakthroughs-in-longevity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/this-years-biggest-breakthroughs-in-longevity","title":{"rendered":"This years biggest breakthroughs in longevity!"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/X-Hzyzo1Jpk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Wrap up for 2025.<\/p>\n<hr>\n<p>Every year I compile what I think were some important contributions to longevity research. Here is my list for 2025!!<\/p>\n<p>Find me on Twitter \u2014 \/ eleanorsheekey.<\/p>\n<p>Support the channel.<br \/> through PayPal \u2014 <a href=\"https:\/\/paypal.me\/sheekeyscience?coun\">https:\/\/paypal.me\/sheekeyscience?coun<\/a>\u2026 through Patreon \u2014 <img alt=\"\" class=\"\"> \/ thesheekeyscienceshow TIMESTAMPS: 00:00 \u2013 Intro &amp; \u201cWhat is aging?\u201d \/ Hallmarks 2025 02:07 \u2013 Cellular reprogramming 05:47 \u2013 Senescent cells 11:45 \u2013 GLP\u20111 agonists &amp; ITP 13:43 \u2013 Elastin fragments &amp; ECM aging 15:22 \u2013 Cardiac \u2018age\u2011switch\u2019 experiment 16:18 \u2013 Systemic environment: FOXO3 cells, antler EVs, plasma exchange 19:26 \u2013 Things you wouldn\u2019t have thought of: AI-predicted antibodies REFERENCES: What is aging \/ hallmarks Hallmarks of aging update 2025 (14 hallmarks, ECM + psychosocial isolation) <a href=\"https:\/\/www.sciencedirect.com\/science\">https:\/\/www.sciencedirect.com\/science<\/a>\u2026 reprogramming Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming \u2013 Cell 2025 <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2025.0\">https:\/\/doi.org\/10.1016\/j.cell.2025.0<\/a>\u2026 A single factor for safer cellular rejuvenation (SB000) \u2013 bioRxiv 2025 <a href=\"https:\/\/doi.org\/10.1101\/2025.06.05.65\">https:\/\/doi.org\/10.1101\/2025.06.05.65<\/a>\u2026 <a href=\"https:\/\/www.biorxiv.org\/content\/10.11\">https:\/\/www.biorxiv.org\/content\/10.11<\/a>\u2026 OpenAI x Retro Biosciences: AI\u2011designed reprogramming factors <a href=\"https:\/\/openai.com\/index\/accelerating\">https:\/\/openai.com\/index\/accelerating<\/a>\u2026 Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche \u2013 Nature Aging 2024 (YouthBio\u2019s scientific basis) <a href=\"https:\/\/doi.org\/10.1038\/s43587-024-00\">https:\/\/doi.org\/10.1038\/s43587-024-00<\/a>\u2026 Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan in Caenorhabditis elegans \u2013 EMBO Molecular Medicine 2025 <a href=\"https:\/\/doi.org\/10.1038\/s44321-025-00\">https:\/\/doi.org\/10.1038\/s44321-025-00<\/a>\u2026 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles<\/a>\u2026 Senescent cells An unbiased cell\u2011culture selection yields DNA aptamers as senescence\u2011specific reagents \u2013 Aging Cell 2025 <a href=\"https:\/\/doi.org\/10.1111\/acel.70245\">https:\/\/doi.org\/10.1111\/acel.70245<\/a> Senolytic CAR T cells reverse senescence\u2011associated pathologies \u2013 Amor et al., Nature 2020 <a href=\"https:\/\/doi.org\/10.1038\/s41586-020-24\">https:\/\/doi.org\/10.1038\/s41586-020-24<\/a>\u2026 Anti\u2011uPAR CAR T cells reverse and prevent aging\u2011associated defects in intestinal regeneration and fitness \u2013 Nature Aging 2025 <a href=\"https:\/\/doi.org\/10.1038\/s43587-025-01\">https:\/\/doi.org\/10.1038\/s43587-025-01<\/a>\u2026 Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low\u2011Frequency Ultrasound \u2013 Aging Cell 2025 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles<\/a>\u2026 Supplements, ITP &amp; GLP\u20111s Are GLP\u20111s the first longevity drugs? \u2013 Nature Biotechnology 2025 <a href=\"https:\/\/doi.org\/10.1038\/s41587-025-02\">https:\/\/doi.org\/10.1038\/s41587-025-02<\/a>\u2026 GLP\u20111 receptor agonists at the crossroads of metabolism and longevity \u2013 Nature Aging <a href=\"https:\/\/www.nature.com\/articles\/s4151\">https:\/\/www.nature.com\/articles\/s4151<\/a>\u2026 Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female UM\u2011HET3 mice \u2013 GeroScience 2025 <a href=\"https:\/\/doi.org\/10.1007\/s11357-025-01\">https:\/\/doi.org\/10.1007\/s11357-025-01<\/a>\u2026 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40973\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40973<\/a>\u2026 ECM, elastin &amp; cardiac environment Elastin\u2011derived extracellular matrix fragments drive aging through innate immune activation \u2013 Nature Aging 2025 <a href=\"https:\/\/doi.org\/10.1038\/s43587-025-00\">https:\/\/doi.org\/10.1038\/s43587-025-00<\/a>\u2026 Sun, A.R., Ramli, M.F.H., Shen, X. et al. Hybrid hydrogel\u2013extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing. Nat. Mater. 24, 1489\u20131501 (2025). <a href=\"https:\/\/doi.org\/10.1038\/s41563-025-02\">https:\/\/doi.org\/10.1038\/s41563-025-02<\/a>\u2026 Systemic environment: stem cells, EVs, plasma Senescence\u2011resistant human mesenchymal progenitor cells counter aging in primates \u2013 Cell 2025 <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2025.0\">https:\/\/doi.org\/10.1016\/j.cell.2025.0<\/a>\u2026 Attenuation of primate aging via systemic infusion of senescence\u2011resistant cells \u2013 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles<\/a>\u2026 Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging\u2011related phenotypes \u2013 Nature Aging 2025 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles<\/a>\u2026 Human clinical trial of plasmapheresis effects on biomarkers of aging \u2013 Aging Cell 2025 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles<\/a>\u2026 \u201cThings you wouldn\u2019t think of\u201d \u2013 AI antibodies Atomically accurate de novo design of antibodies with atomic precision \u2013 Baker Lab, Nature 2025 <a href=\"https:\/\/doi.org\/10.1038\/s41586-025-09\">https:\/\/doi.org\/10.1038\/s41586-025-09<\/a>\u2026 Computational design of human antibodies targeting any antigen \u2013 <a href=\"https:\/\/doi.org\/10.1016\/j.cell.2025.1\">https:\/\/doi.org\/10.1016\/j.cell.2025.1<\/a>\u2026 Please note that The Sheekey Science Show is distinct from Eleanor Sheekey\u2019s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; \u201chttps:\/\/www.freepik.com\/free-photos-v\u2026\u201cBackground vector created by freepik \u2014 <a href=\"http:\/\/www.freepik.com\">www.freepik.com<\/a>.<br \/> through Patreon \u2014 \/ thesheekeyscienceshow.<\/p>\n<p>TIMESTAMPS:<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/01\/this-years-biggest-breakthroughs-in-longevity\">Continue reading \u201cThis years biggest breakthroughs in longevity!\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wrap up for 2025. Every year I compile what I think were some important contributions to longevity research. Here is my list for 2025!! Find me on Twitter \u2014 \/ eleanorsheekey. Support the channel. through PayPal \u2014 https:\/\/paypal.me\/sheekeyscience?coun\u2026 through Patreon \u2014 \/ thesheekeyscienceshow TIMESTAMPS: 00:00 \u2013 Intro &amp; \u201cWhat is aging?\u201d \/ Hallmarks 2025 02:07 [\u2026]<\/p>\n","protected":false},"author":740,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,269,6],"tags":[],"class_list":["post-228855","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-life-extension","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/740"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228855"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228855\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}