{"id":228783,"date":"2026-01-11T00:31:26","date_gmt":"2026-01-11T06:31:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/autonomous-sting-signaling-in-purkinje-cells-drives-neurodegeneration-independent-of-type-i-interferon"},"modified":"2026-01-11T00:31:26","modified_gmt":"2026-01-11T06:31:26","slug":"autonomous-sting-signaling-in-purkinje-cells-drives-neurodegeneration-independent-of-type-i-interferon","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/autonomous-sting-signaling-in-purkinje-cells-drives-neurodegeneration-independent-of-type-i-interferon","title":{"rendered":"Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/autonomous-sting-signaling-in-purkinje-cells-drives-neurodegeneration-independent-of-type-i-interferon2.jpg\"><\/a><\/p>\n<p>Microglial STING-type I interferon signaling is known to play a role in neuroinflammation and neurodegeneration. Yang et al. find that STING is also expressed in Purkinje neurons. STING activation dysregulates the autonomous firing and pace-making function of Purkinje neurons independently of interferon signaling, leading to neurodegeneration and cerebellar ataxia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microglial STING-type I interferon signaling is known to play a role in neuroinflammation and neurodegeneration. Yang et al. find that STING is also expressed in Purkinje neurons. STING activation dysregulates the autonomous firing and pace-making function of Purkinje neurons independently of interferon signaling, leading to neurodegeneration and cerebellar ataxia.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-228783","post","type-post","status-publish","format-standard","hentry","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228783"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228783\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}