{"id":228654,"date":"2026-01-09T17:18:39","date_gmt":"2026-01-09T23:18:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/loss-of-lipin1-contributes-to-multiple-pathological-processes-in-the-development-of-heart-failure"},"modified":"2026-01-09T17:18:39","modified_gmt":"2026-01-09T23:18:39","slug":"loss-of-lipin1-contributes-to-multiple-pathological-processes-in-the-development-of-heart-failure","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/loss-of-lipin1-contributes-to-multiple-pathological-processes-in-the-development-of-heart-failure","title":{"rendered":"Loss of Lipin1 Contributes to Multiple Pathological Processes in the Development of Heart Failure"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/loss-of-lipin1-contributes-to-multiple-pathological-processes-in-the-development-of-heart-failure2.jpg\"><\/a><\/p>\n<p>Loss of <i>lipin1<\/i> disrupts heart muscle membrane integrity, driving inflammation, fibrosis, and contributing to heart failure.<\/p>\n<hr>\n<p>BackgroundLipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that <i>lipin1<\/i> is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability for cardiac muscle viability and function, we investigated the role of <i>lipin1<\/i> in the heart using a novel cardiac\u2010specific <i>lipin1<\/i> deficient (<i><i>Myh6\u2010lipin <\/i>1<\/i><sup>\u2212\/\u2212<\/sup>) mouse model.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Loss of lipin1 disrupts heart muscle membrane integrity, driving inflammation, fibrosis, and contributing to heart failure. BackgroundLipin1 has dual functions acting as phosphatidic acid phosphatase required for lipid synthesis and as a transcriptional coactivator. Our previous research demonstrated that lipin1 is critical for maintaining sarcolemmal integrity in skeletal muscle. Given the importance of sarcolemmal stability [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-228654","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228654"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228654\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}