{"id":228574,"date":"2026-01-08T05:05:44","date_gmt":"2026-01-08T11:05:44","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/crispri-screening-in-cultured-human-astrocytes-uncovers-distal-enhancers-controlling-genes-dysregulated-in-alzheimers-disease"},"modified":"2026-01-08T05:05:44","modified_gmt":"2026-01-08T11:05:44","slug":"crispri-screening-in-cultured-human-astrocytes-uncovers-distal-enhancers-controlling-genes-dysregulated-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/crispri-screening-in-cultured-human-astrocytes-uncovers-distal-enhancers-controlling-genes-dysregulated-in-alzheimers-disease","title":{"rendered":"CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer\u2019s disease"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispri-screening-in-cultured-human-astrocytes-uncovers-distal-enhancers-controlling-genes-dysregulated-in-alzheimers-disease.jpg\"><\/a><\/p>\n<p>2026 (<i><i>Nature<\/i> Neuroscience<\/i>) <\/p>\n<p>\u2022 AstroREG, a resource of enhancer\u2013gene interactions in human primary astrocytes, generated by combining CRISPR inhibition (CRISPRi), single-cell RNA-seq and machine learning.<\/p>\n<hr>\n<p>This study reveals how distal DNA \u2018switches\u2019 control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer\u2013gene links, highlight Alzheimer\u2019s disease-related targets and introduce a model that predicts additional regulatory interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026 (Nature Neuroscience) \u2022 AstroREG, a resource of enhancer\u2013gene interactions in human primary astrocytes, generated by combining CRISPR inhibition (CRISPRi), single-cell RNA-seq and machine learning. This study reveals how distal DNA \u2018switches\u2019 control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer\u2013gene links, highlight Alzheimer\u2019s disease-related targets and introduce a [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-228574","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228574"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228574\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}