{"id":228392,"date":"2026-01-05T17:15:37","date_gmt":"2026-01-05T23:15:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/chemogenetic-attenuation-of-cortical-seizures-in-nonhuman-primates"},"modified":"2026-01-05T17:15:37","modified_gmt":"2026-01-05T23:15:37","slug":"chemogenetic-attenuation-of-cortical-seizures-in-nonhuman-primates","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/chemogenetic-attenuation-of-cortical-seizures-in-nonhuman-primates","title":{"rendered":"Chemogenetic attenuation of cortical seizures in nonhuman primates"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/chemogenetic-attenuation-of-cortical-seizures-in-nonhuman-primates.jpg\"><\/a><\/p>\n<p>A great paper where Miyakawa <i>et al.<\/i> show attenuation of seizures using chemogenetics for the first time in a nonhuman primate model of epilepsy. I hope chemogenetics moves into clinical trials soon (this paper was published in 2023), it seems very promising as a therapeutic modality. [ <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36642-6\">https:\/\/www.nature.com\/articles\/s41467-023-36642-6<\/a>](<a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36642-6\">https:\/\/www.nature.com\/articles\/s41467-023-36642-6<\/a>) <\/p>\n<hr>\n<p>Pharmacological and surgical treatments of epilepsy can have unsatisfactory outcomes, so a more targeted and on-demand approach is desirable. Here, the authors demonstrate the usage of inhibitory chemogenetics in male nonhuman primates to attenuate the magnitude and spread of cortical seizures and subsequent body convulsions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A great paper where Miyakawa et al. show attenuation of seizures using chemogenetics for the first time in a nonhuman primate model of epilepsy. I hope chemogenetics moves into clinical trials soon (this paper was published in 2023), it seems very promising as a therapeutic modality. [ https:\/\/www.nature.com\/articles\/s41467-023-36642-6](https:\/\/www.nature.com\/articles\/s41467-023-36642-6) Pharmacological and surgical treatments of epilepsy can [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-228392","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228392","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228392"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228392\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}