{"id":228349,"date":"2026-01-05T01:08:27","date_gmt":"2026-01-05T07:08:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/small-interfering-rna-olpasiran-and-apolipoprotein-b-particles"},"modified":"2026-01-05T01:08:27","modified_gmt":"2026-01-05T07:08:27","slug":"small-interfering-rna-olpasiran-and-apolipoprotein-b-particles","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/small-interfering-rna-olpasiran-and-apolipoprotein-b-particles","title":{"rendered":"Small-Interfering RNA Olpasiran and Apolipoprotein B Particles"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/small-interfering-rna-olpasiran-and-apolipoprotein-b-particles.png\"><\/a><\/p>\n<p>Small-interfering RNA olpasiran reduced lipoprotein(a)\u2013apolipoprotein B particles by 95% with minimal rise in non\u2013Lp(a)-apoB, lowering total apoB concentration in patients with cardiovascular disease.<\/p>\n<hr>\n<p>This secondary analysis of the OCEAN(a)-DOSE randomized clinical trial investigates the effect of the small-interfering RNA olpasiran on atherogenic lipoproteins.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Small-interfering RNA olpasiran reduced lipoprotein(a)\u2013apolipoprotein B particles by 95% with minimal rise in non\u2013Lp(a)-apoB, lowering total apoB concentration in patients with cardiovascular disease. This secondary analysis of the OCEAN(a)-DOSE randomized clinical trial investigates the effect of the small-interfering RNA olpasiran on atherogenic lipoproteins.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-228349","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228349"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228349\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}