{"id":228197,"date":"2026-01-02T01:06:07","date_gmt":"2026-01-02T07:06:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/chrono-immune-neuropathy-during-pd-1-blockade-a-report-of-a-fatal-case-and-hypothesis-on-circadian-modulation-of-neurotoxicity"},"modified":"2026-01-02T01:06:07","modified_gmt":"2026-01-02T07:06:07","slug":"chrono-immune-neuropathy-during-pd-1-blockade-a-report-of-a-fatal-case-and-hypothesis-on-circadian-modulation-of-neurotoxicity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/chrono-immune-neuropathy-during-pd-1-blockade-a-report-of-a-fatal-case-and-hypothesis-on-circadian-modulation-of-neurotoxicity","title":{"rendered":"Chrono-Immune Neuropathy During PD-1 Blockade: A Report of a Fatal Case and Hypothesis on Circadian Modulation of Neurotoxicity"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/chrono-immune-neuropathy-during-pd-1-blockade-a-report-of-a-fatal-case-and-hypothesis-on-circadian-modulation-of-neurotoxicity.jpg\"><\/a><\/p>\n<p>Immune checkpoint inhibitors can cause a wide spectrum of immune-related adverse events, including rare but severe neurological complications. This report describes a fatal case of progressive immune-mediated neuropathy in a melanoma patient treated with PD-1 blockade, in whom worsening neuropathic pain and functional decline coincided with irregular, non-aligned timing of immunotherapy infusions. PET-CT imaging, MRI, and laboratory testing excluded metastatic, infectious, metabolic, and paraneoplastic causes. Longitudinal evaluation revealed fluctuations in inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), with peaks occurring shortly after late-afternoon infusions. Earlier infusions were associated with fewer symptoms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immune checkpoint inhibitors can cause a wide spectrum of immune-related adverse events, including rare but severe neurological complications. This report describes a fatal case of progressive immune-mediated neuropathy in a melanoma patient treated with PD-1 blockade, in whom worsening neuropathic pain and functional decline coincided with irregular, non-aligned timing of immunotherapy infusions. PET-CT imaging, MRI, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-228197","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228197"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228197\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}