{"id":228192,"date":"2026-01-01T21:27:03","date_gmt":"2026-01-02T03:27:03","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/butyrolactol-a-enhances-caspofungin-efficacy-via-flippase-inhibition-in-drug-resistant-fungi"},"modified":"2026-01-01T21:27:03","modified_gmt":"2026-01-02T03:27:03","slug":"butyrolactol-a-enhances-caspofungin-efficacy-via-flippase-inhibition-in-drug-resistant-fungi","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/butyrolactol-a-enhances-caspofungin-efficacy-via-flippase-inhibition-in-drug-resistant-fungi","title":{"rendered":"Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/butyrolactol-a-enhances-caspofungin-efficacy-via-flippase-inhibition-in-drug-resistant-fungi2.jpg\"><\/a><\/p>\n<p>Chen et al. identify the natural product butyrolactol A as an inhibitor of the phospholipid flippase Apt1-Cdc50, which it locks in a nonfunctional state. By disrupting membrane homeostasis and enhancing drug uptake, butyrolactol A restores echinocandin efficacy against intrinsically resistant fungal pathogens, including <i>Cryptococcus<\/i> and Candida auris.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chen et al. identify the natural product butyrolactol A as an inhibitor of the phospholipid flippase Apt1-Cdc50, which it locks in a nonfunctional state. By disrupting membrane homeostasis and enhancing drug uptake, butyrolactol A restores echinocandin efficacy against intrinsically resistant fungal pathogens, including Cryptococcus and Candida auris.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-228192","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228192","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228192"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228192\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}