{"id":228183,"date":"2026-01-01T21:22:56","date_gmt":"2026-01-02T03:22:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/01\/injury-and-inflammation-promote-cancer-progression-at-the-anorectal-junction"},"modified":"2026-01-01T21:22:56","modified_gmt":"2026-01-02T03:22:56","slug":"injury-and-inflammation-promote-cancer-progression-at-the-anorectal-junction","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/01\/injury-and-inflammation-promote-cancer-progression-at-the-anorectal-junction","title":{"rendered":"Injury and inflammation promote cancer progression at the anorectal junction"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/injury-and-inflammation-promote-cancer-progression-at-the-anorectal-junction2.jpg\"><\/a><\/p>\n<p>Petitpas et al. dissect the single-cell transcriptome underlying the sequential steps of pre-malignant lesions and early anorectal cancer, mimicking disease evolution seen in patients, at the epithelial and immune level. They reveal a key epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Petitpas et al. dissect the single-cell transcriptome underlying the sequential steps of pre-malignant lesions and early anorectal cancer, mimicking disease evolution seen in patients, at the epithelial and immune level. They reveal a key epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,385],"tags":[],"class_list":["post-228183","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-evolution"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228183"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228183\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}