{"id":228157,"date":"2025-12-31T21:13:56","date_gmt":"2026-01-01T03:13:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/rad53-regulates-rnase-h1-which-promotes-dna-replication-through-sites-of-transcription-replication-conflict"},"modified":"2025-12-31T21:13:56","modified_gmt":"2026-01-01T03:13:56","slug":"rad53-regulates-rnase-h1-which-promotes-dna-replication-through-sites-of-transcription-replication-conflict","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/rad53-regulates-rnase-h1-which-promotes-dna-replication-through-sites-of-transcription-replication-conflict","title":{"rendered":"Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/rad53-regulates-rnase-h1-which-promotes-dna-replication-through-sites-of-transcription-replication-conflict2.jpg\"><\/a><\/p>\n<p>Wagner et al. demonstrate that RNase H1 only removes a subset of R-loops <i>in vivo.<\/i> In yeast, overexpressed RNH1 acts more frequently at dysregulated R-loops and infrequently, if at all, at other RNA-DNA hybrids. Endogenous Rnh1 is induced in a Rad53-dependent manner at transcription-replication conflicts to promote replication completion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wagner et al. demonstrate that RNase H1 only removes a subset of R-loops in vivo. In yeast, overexpressed RNH1 acts more frequently at dysregulated R-loops and infrequently, if at all, at other RNA-DNA hybrids. Endogenous Rnh1 is induced in a Rad53-dependent manner at transcription-replication conflicts to promote replication completion.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-228157","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=228157"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/228157\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=228157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=228157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=228157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}