{"id":227914,"date":"2025-12-27T13:12:58","date_gmt":"2025-12-27T19:12:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/id1-boosts-antiviral-immunity-by-countering-prmt5-mediated-sting-methylation"},"modified":"2025-12-27T13:12:58","modified_gmt":"2025-12-27T19:12:58","slug":"id1-boosts-antiviral-immunity-by-countering-prmt5-mediated-sting-methylation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/id1-boosts-antiviral-immunity-by-countering-prmt5-mediated-sting-methylation","title":{"rendered":"ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/id1-boosts-antiviral-immunity-by-countering-prmt5-mediated-sting-methylation2.jpg\"><\/a><\/p>\n<p>Li et al. report that ID1 sustains STING activation and innate immunity by blocking PRMT5-STING binding, thereby preventing PRMT5-mediated methylation at Arg281 of STING. The PRMT5 inhibitor EPZ015666 enhances STING activation by suppressing PRMT5, providing a therapeutic candidate for antiviral treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. report that ID1 sustains STING activation and innate immunity by blocking PRMT5-STING binding, thereby preventing PRMT5-mediated methylation at Arg281 of STING. The PRMT5 inhibitor EPZ015666 enhances STING activation by suppressing PRMT5, providing a therapeutic candidate for antiviral treatment.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-227914","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227914"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227914\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}