{"id":227760,"date":"2025-12-24T10:14:26","date_gmt":"2025-12-24T16:14:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/pathways-of-pain"},"modified":"2025-12-24T10:14:26","modified_gmt":"2025-12-24T16:14:26","slug":"pathways-of-pain","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/pathways-of-pain","title":{"rendered":"Pathways of pain"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pathways-of-pain2.jpg\"><\/a><\/p>\n<p>A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new <i>Science<\/i> study. The findings provide a pathway toward targeted therapeutic strategies.<\/p>\n<p>Learn more in a new <i>Science<\/i> Perspective.<\/p>\n<hr>\n<p>Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain.<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed4888#con1\"> Am\u00e9lie Joly<\/a> and <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed4888#con2\"> Irene Miguel-Aliaga<\/a> <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed4888#tab-contributors\">Authors Info &amp; Affiliations<\/a><\/p>\n<p><i>Science<\/i><\/p>\n<p>Vol 390, Issue 6779<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/12\/pathways-of-pain\">Continue reading \u201cPathways of pain\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies. Learn more in a new Science Perspective. Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain. Am\u00e9lie Joly and [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-227760","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227760"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227760\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}