{"id":227630,"date":"2025-12-22T17:11:32","date_gmt":"2025-12-22T23:11:32","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/prolonging-lung-cancer-response-to-egfr-inhibition-by-targeting-the-selective-advantage-of-resistant-cells"},"modified":"2025-12-22T17:11:32","modified_gmt":"2025-12-22T23:11:32","slug":"prolonging-lung-cancer-response-to-egfr-inhibition-by-targeting-the-selective-advantage-of-resistant-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/prolonging-lung-cancer-response-to-egfr-inhibition-by-targeting-the-selective-advantage-of-resistant-cells","title":{"rendered":"Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/prolonging-lung-cancer-response-to-egfr-inhibition-by-targeting-the-selective-advantage-of-resistant-cells.jpg\"><\/a><\/p>\n<p>The emergence of resistant subpopulations often underlies the development of resistance to cancer therapy. Here, using a DNA barcoding approach, the authors demonstrate EGFR TKI treatment in non-small cell lung cancer enriches for resistant subpopulation which can be prevented by treatment with the multikinase inhibitor sorafenib via inhibition of MKNK, STAT3 and MCL1.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The emergence of resistant subpopulations often underlies the development of resistance to cancer therapy. Here, using a DNA barcoding approach, the authors demonstrate EGFR TKI treatment in non-small cell lung cancer enriches for resistant subpopulation which can be prevented by treatment with the multikinase inhibitor sorafenib via inhibition of MKNK, STAT3 and MCL1.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-227630","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227630"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227630\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}