{"id":227623,"date":"2025-12-22T14:10:59","date_gmt":"2025-12-22T20:10:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/ready-made-t-cell-gene-therapy-tackles-incurable-t-cell-leukemia"},"modified":"2025-12-22T14:10:59","modified_gmt":"2025-12-22T20:10:59","slug":"ready-made-t-cell-gene-therapy-tackles-incurable-t-cell-leukemia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/ready-made-t-cell-gene-therapy-tackles-incurable-t-cell-leukemia","title":{"rendered":"\u2018Ready-made\u2019 T-cell gene therapy tackles \u2018incurable\u2019 T-cell leukemia"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ready-made-t-cell-gene-therapy-tackles-incurable-t-cell-leukemia.jpg\"><\/a><\/p>\n<p>A new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).<\/p>\n<p>The world-first gene therapy (BE-CAR7) uses base-edited immune cells to treat previously untreatable T-cell leukemia and help patients achieve remission, offering new hope for families facing this aggressive cancer. <a href=\"https:\/\/phys.org\/news\/2023-01-crispr-gene-editing-tool.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\" target=\"_blank\">Base-editing<\/a> is an advanced version of CRISPR technology, that can precisely change single letters of DNA code inside living cells.<\/p>\n<p>In 2022, researchers from GOSH and UCL delivered the world\u2019s first treatment made using \u201cbase-editing\u201d to a 13-year-old girl from Leicester, Alyssa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL). The world-first gene therapy (BE-CAR7) uses base-edited immune cells to [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-227623","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227623"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227623\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}