{"id":227565,"date":"2025-12-20T21:09:12","date_gmt":"2025-12-21T03:09:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/chromosome-shattering-in-cancer"},"modified":"2025-12-20T21:09:12","modified_gmt":"2025-12-21T03:09:12","slug":"chromosome-shattering-in-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/chromosome-shattering-in-cancer","title":{"rendered":"Chromosome shattering in cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/chromosome-shattering-in-cancer2.jpg\"><\/a><\/p>\n<p>Cancer cells often contain an abnormal number of chromosomes as a result of incorrect chromosome segregation during cell division.<\/p>\n<p>These fragments of genetic material can be encapsulated by a membrane, forming small nucleus-like structures called micronuclei. These structures often rupture, exposing chromatin (DNA and associated proteins) to the harsh environment of the cytoplasm, which can lead to large-scale DNA damage in a process called chromothripsis, or chromosome shattering and scrambling.<\/p>\n<p>In a new <i>Science<\/i> study, researchers report that the cytoplasmic protein NEDD4-binding protein 2 may be responsible for chromothripsis.<\/p>\n<p>Learn more in a new.<\/p>\n<hr>\n<p>A protein that cuts double-stranded DNA contributes to chromosome scrambling in human cancer cells.<\/p>\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed1825#con1\"> Stanley Clarke<\/a> and <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed1825#con2\"> Marcin Imieli\u0144ski<\/a> <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aed1825#tab-contributors\">Authors Info &amp; Affiliations<\/a><\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2025\/12\/chromosome-shattering-in-cancer\">Continue reading \u201cChromosome shattering in cancer\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cancer cells often contain an abnormal number of chromosomes as a result of incorrect chromosome segregation during cell division. These fragments of genetic material can be encapsulated by a membrane, forming small nucleus-like structures called micronuclei. These structures often rupture, exposing chromatin (DNA and associated proteins) to the harsh environment of the cytoplasm, which can [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-227565","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227565"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227565\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}