{"id":227539,"date":"2025-12-20T09:32:09","date_gmt":"2025-12-20T15:32:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/pineal-gland-senescence-an-emerging-ageing-related-pathology"},"modified":"2025-12-20T09:32:09","modified_gmt":"2025-12-20T15:32:09","slug":"pineal-gland-senescence-an-emerging-ageing-related-pathology","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/pineal-gland-senescence-an-emerging-ageing-related-pathology","title":{"rendered":"Pineal gland senescence: an emerging ageing-related pathology?"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pineal-gland-senescence-an-emerging-ageing-related-pathology2.jpg\"><\/a><\/p>\n<p>An ageing-related pathology has recently been described as one that develops and\/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle environmental cues. The gland may undergo ageing-related structural and morphological changes, including calcification, gliosis, cyst formation, and reduced density of \u03b2-adrenergic receptors, which are hypothesised to reduce melatonin secretion.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An ageing-related pathology has recently been described as one that develops and\/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline and that is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to light-dark cycle [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-227539","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227539"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227539\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}